Faculty Research

Parker Antin -- Molecular regulation of vertebrate development.

Vahe Bandarian -- Biosynthesis of secondary metabolites; mechanistic enzymology.

Giovanni Bosco -- Developmental regulation of the cell cycle; DNA replication; Drosophila as a cancer model.

G. Tim Bowden -- Molecular mechanisms of radiation and chemical carcinogenesis, chemoprevention of cancer.

Murray H. Brilliant -- Genetic and molecular analyses of mouse and human mutations affecting pigmentation and development.

Michael F. Brown -- Nuclear magnetic resonance spectroscopy; membrane proteins; chemistry of membranes and liquid crystals; molecular basis of vision.

Gail D. Burd -- Development of the nervous system: Role of early development genes, sensory afferents, and hormones.

Todd Camenisch -- Focus is investigating the integration between extracellular matrix and growth factor receptor signaling during heart morphogenesis. The emphasis is on heart septae and valve formation.

Andrew Capaldi - The signaling pathways and transcription factors in a cell are organized into circuits that allow cells to process information and make decisions. We are interested in understanding both how these circuits are built from their components and how they function and malfunction. To address these questions we are working to reverse engineer the circuitry that controls cell growth in budding yeast using a combination of genomic, proteomic and computational methods.

Vicki L. Chandler -- Genetic mechanisms controlling tissue-specific and developmental gene expression.

Matthew H.J. Cordes -- Evolution of the structure and function of proteins; conformational change in proteins.

Anne E. Cress -- Molecular mechanisms of cell adhesion and human tumor progression.

Michael A. Cusanovich -- Protein structure and function, biological electron transfer, sensor proteins, bacterial evolution.

Bradley Davidson -- We study heart development in the primitive chordate, Ciona intestinalis.  The simplicity of this organism allows us to decipher conserved transcriptional and cellular events underlying the earliest steps of heart formation.

Carol L. Dieckmann -- Mitochondrial RNA stability; Chlamydomonas eyespot positioning and assembly.

Kathleen Dixon -- Response of the mammalian cell DNA replication complex to template damage; protein phosphorylation in the DNA damage response; genotoxic effects of chromium and arsenic.

Robert P. Erickson -- Mammalian developmental and molecular genetics and medical genetics.

Hanna (Johnny) Fares -- Analysis of membrane trafficking; Caenorhabditis elegans as a model system.

David Gang -- Plant specialized metabolism (secondary metabolism); evolution of plant metabolic pathways; genomics-based approaches to elucidate biosynthetic pathways (biochemical genomics); function of plant natural products.

Sandra J. Gendler -- Mucin glycoproteins in disease.

Eugene W. Gerner -- Regulation of cell growth and apoptosis; carcinogenesis; polyamine metabolism; cancer prevention and treatment.

Felicia Goodrum -- Human cytomegalovirus infection and latency in primary human hematopoietic cells, viral patogenesis.

Herman Gordon -- Molecular basis of synaptogenesis.

Henk L. Granzier -- Role of the filamentous proteins titin and nebulin in function of normal and diseased muscle.

Carol C. Gregorio -- Cytoskeletal protein interactions in heart and skeletal muscle development.

Vincent Guerriero -- Regulation of cellular stress response.

Erik J. Henriksen -- Regulation of the glucose transport system in normal and insulin-resistant skeletal muscle.

John G. Hildebrand -- Behavioral, cellular, developmental, molecular, and systems neurobiology of insects.

Nancy Horton -- Protein-nucleic acid recognition, enzymology, X-ray crystallography, kinetics, protein dynamics, DNA repair.

Victor J. Hruby -- Peptide hormone and neurotransmitter conformation-bioactivity relationships; brain chemistry; combinatorial chemistry; peptidomimetics; and G-protein coupled receptors (GPCRs). Relationships to pain, cancer, diabetes, feeding behavior, sexual behavior, inflammation, etc. Multimeric and multivalent ligands for detection and treatment of disease.

Paul A. Krieg -- Organogenesis; development of the vertebrate heart and blood vessels.

Josephine Lai -- Pharmacology of neuropathic pain, using nerve ligation injury in the rat as a model.

M. Peter Lance -- Molecular mechanisms of stromal fibroblasts and their role in colorectal carcinogenesis.

Brian A. Larkins --Genetic and biochemical regulation of plant seed development and protein nutritional quality.

John W. Little -- Mechanisms of gene regulation; behavior and evolution of gene regulatory circuits.

Joseph C. Loftus -- Integrin adhesion and signaling in vascular cell biology.

Megan McEvoy -- Structure/function of protein complexes; NMR; structure and function of proteins involved in asymmetric cell division in Drosophila neuroblasts.

Emmanuelle Meuillet -- My research interests are focused on the regulation of the tumor suppressor, PTEN, and the survival pathway (PtdIns-3-Kinase/Akt/ PTEN) and its importance in cancer and diabetes.

Roger L. Miesfeld -- Molecular genetics of cell signaling.

Osamu Miyashita -- Theoretical and computational biophysics, molecular dynamics simulations, protein electron transfer, protein allostery.

William R. Montfort -- Protein structure, function, and inhibition.

Lisa M. Nagy -- Analysis of the genetic basis of morphological diversification.

Alan Nighorn -- Understanding signal transduction in the adult and developing olfactory system.

Howard Ochman -- Molecular evolution of bacterial genes and genomes.

Ravi Palanivelu - Isolation and characterization of pollen tube guidance signals during plant reproduction.

Roy Parker -- Molecular genetics of yeast to examine mechanisms and regulation of mRNA turnover.

Priscilla Schaffer -- Genetics and molecular biology of herpes simplex virus gene expression, latency, and reactivation.

Joyce Schroeder -- Molecular mechanisms of breast cancer progression.

Karen S. Schumaker -- Molecular genetic mechanisms controlling plant development and plant adaptation to abiotic stress.

Magdalene So --

Matthew B. Sullivan -- The lab is focused in three primary research areas:  Cyanophages, Roseophages, Sea of Cortez Project.  Through the use of (meta)genomics, we query 'wild' viral populations to identify important hypotheses that can be evaluated using model-system approaches with appropriate cyanophage and/or roseophage isolates.

Florence Tama -- Computational structural biology; function and dynamics of macromolecular assemblies; multi-scale modeling; methods development to interpret experimental data.

Frans Tax -- Functions of plant receptor kinases and their signaling pathways.

Tsu-Shuen Tsao -- Obesity and type II diabetes mellitus; hormonal regulation of energy homeostasis; signal transduction pathways involved in cellular and whole body energetics; and structure function relationship of adipocyte-derived hormones.

Hans D. VanEtten -- Molecular mechanisms of plant pathogenesis, habitat specific genes on dispensable chromosomes, and synthesis of plant antibiotics.

Elizabeth Vierling -- Biochemistry and function of molecular chaperones, plant molecular biology.

Koen Visscher -- Molecular motors.

F. Ann Walker -- Bioinorganic chemistry of hemes and heme proteins; electrochemistry; NMR and EPR spectroscopy.

Bruce Walsh -- Molecular evolution, genomics, population and quantitative genetics.

Ted A. Weinert -- Cell cycle checkpoints that arrest cell division after DNA damage.

Stephen Wright -- Mechanisms of membrane transport.

Vicki Wysocki -- Bioanalytical mass spectrometry/peptide and protein sequencing/ ion-surface collisions for surface characterization of organic thin film.

Ramin Yadegari -- Molecular mechanisms of early development in plants; epigenetic regulation of gene expression and imprinting.

Daniela C. Zarnescu -- Molecular mechanisms for neural development and polarity; mRNA transport in neurons; Local translational control; Fragile X syndrome; Cell polarity and tumor suppressors; miRNA pathway.

Konrad E. Zinsmaier -- Synaptic function.

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