Genetics and molecular biology of herpes simplex virus gene expression, latency, and reactivation.
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Balliet, J.W., J.C. Min, J.J. Bowman, C. Chow, G.T. Melroe, D.M. Coen, D.M. Knipe, and P.A. Schaffer. Mutations in herpes simplex virus type I early genes have differential effects on transcription of viral immediate-early genes. (Manuscript in Preparation)
Link, M.A., L.A. Silva, and P.A. Schaffer. 2007. Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication. Journal of Virology 81: 9175-9182.
Link, M.A., and P.A. Schaffer. 2007. Herpes simplex virus type-1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2 cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice. Journal of Virology 81: 10699-10711.
Melroe, G.T., L. Silva, P.A. Schaffer, and D.M. Knipe. 2007. Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: potential role in blocking IFN-beta induction. Virology 360: 305-321.
Balliet, J.W., A. Kushnir, and P.A. Schaffer. 2007. Construction and characterization of a herpes simplex virus type I recombinant expressing green fluorescent protein: Acute phase replication and reactivation in mice. Virology 361: 372-383.
Orlando, J.S., J.W. Balliet, A.S. Kushnir, T.L. Astor, M. Kosz-Vnenchak, S.A. Rice, D.M. Knipe, and P.A. Schaffer. 2006. ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions. Journal of Virology 80: 9381-9390.
Bringhurst, R.M., and P.A. Schaffer. 2006. Cellular stress rather than stage of the cell cycle enhances the replication and plating efficiencies of HSV-1 ICP0- viruses. Journal of Virology 80: 4528-4537.
Orlando, J.S., T.L. Astor, S.A. Rundle, and P.A. Schaffer. 2006. The products of the HSV-1 immediate early Us1/Us1.5 genes downregulate levels of S phase-specific cyclins and facilitate virus replication in S phase Vero cells. Journal of Virology 80: 4005-4016.
Balliet, J.W., and P.A. Schaffer. 2006. Point mutations in herpes simplex virus type 1 OriL, but not in OriS, reduce pathogenesis during acute infection of mice and impair reactivation from latency. Journal of Virology 80: 440-450.
Balliet, J.W., J.C. Min, M.S. Cabatingan, and P.A. Schaffer. 2005. Site-directed mutagenesis of large DNA palindromes: Construction and in vitro characterization of herpes simplex virus type 1 mutants containing point mutations that eliminate OriL or OriS initiation function. Journal of Virology 79: 12783-12797.
Davido, D.J., W.F. von Zagorski, W.S. Lane, and P.A. Schaffer. 2005. Phosphorylation site mutations affect herpes simplex virus type 1 ICP0 function. Journal of Virology 79: 1232-1243.
