H. Vasken Aposhian

Professor of Molecular & Cellular Biology
Ph.D., University of Rochester, 1953

Environmental, cellular, and molecular toxicology.

Research Interests

Select Publications

Any link on the below references will take you off of the BMCB site and to an abstract of that particular paper.

Aposhian H.V., and M.M. Aposhian. 2006. Arsenic toxicology: five questions. Chemical Research in Toxicology 19: 1-15.

Zakharyan, R.A., G. Tsaprailis, U.K. Chowdhury, A. Hernandez, and H.V. Aposhian HV. 2005. Interactions of sodium selenite, glutathione, arsenic species, and omega class human glutathione transferase. Chemical Research in Toxicology 18: 1287-1295.

Aposhian, H.V., R.A. Zakharyan, M.D. Avram, A. Sampayo-Reyes, and M.L. Wollenberg. 2004. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicology and Applied Pharmacology 198: 327-335.

Marnell, L.L., G.G. Garcia-Vargas, U.K. Chowdhury, R.A. Zakharyan, B. Walsh, M.D. Avram, M.J. Kopplin, M.E. Cebrian, E.K. Silbergeld, and H.V. Aposhian. 2003. Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles. Chemical Research in Toxicology 16: 1507-1513.

Carter, D.E., H.V. Aposhian, and A.J. Gandolfi. 2003. The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review. Toxicology and Applied Pharmacology 193: 309-334.

Aposhian, H.V., R.A. Zakharyan, M.D. Avram, M.J. Kopplin, and M.L. Wollenberg. Oxidation and detoxification of trivalent arsenic species. Toxicology and Applied Pharmacology 193: 1-8.

Aposhian, H.V., D.L. Morgan, H.L. Queen, R.M. Maiorino, and M.M. Aposhian. 2003. Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor. Jouornal of Toxicology. Clinical Toxicology 41: 339-347.

Loffredo, C.A., H.V. Aposhian, M.E. Cebrian, H. Yamauchi, and E.K. Silbergeld. 2003. Variability in human metabolism of arsenic. Environmental Research 92: 85-91.

Gong, Z., G. Jiang, W.R. Cullen, H.V. Aposhian, and X.C. Le. 2002. Determination of arsenic metabolic complex excreted in human urine after administration of sodium 2,3-dimercapto-1-propane sulfonate. Chemical Research in Toxicology 15: 1318-1323.

Radabaugh, T.R., A. Sampayo-Reyes, R.A. Zakharyan, and H.V. Aposhian. 2002. Arsenate reductase II. Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. Chemical Research in Toxicology 15: 692-698.

Liu, J., B. Zheng, H.V. Aposhian, Y. Zhou, M.L. Chen, A. Zhang, and M.P. Waalkes. 2002. Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China. Environmental Health Perspectives 110: 119-122.

Zakharyan, R.A., A. Sampayo-Reyes, S.M. Healy, G. Tsaprailis, P.G. Board, D.C. Liebler, and H.V. Aposhian. 2001. Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. Chemical Research in Toxicology 14: 1051-1057.

Petrick, J.S., B. Jagadish, E.A. Mash, and H.V. Aposhian. 2001. Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chemical Research in Toxicology 14: 651-656.

Le, X.C., M. Ma, W.R. Cullen, H.V. Aposhian, X. Lu, and B. Zheng. 2000. Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. Environmental Health Perspectives 108: 1015-1018.

Sampayo-Reyes, A., R.A. Zakharyan, S.M. Healy, and H.V. Aposhian. 2000. Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. Chemical Research in Toxicology 13: 1181-1186.

Gailer, J., G.N. George, I.J. Pickering, S. Madden, R.C. Prince, E.Y. Yu, M.B. Denton, H.S. Younis, and H.V. Aposhian. 2000. Structural basis of the antagonism between inorganic mercury and selenium in mammals. Chemical Research in Toxicology 13: 1135-1142.

Le, X.C., X. Lu, M. Ma, W.R. Cullen, H.V. Aposhian, and B. Zheng. 2000. Speciation of key arsenic metabolic intermediates in human urine. Analytical Chemistry 72: 5172-5177.

Aposhian, H.V., E.S. Gurzau, X.C. Le, A. Gurzau, S.M. Healy, X. Lu, M. Ma, L. Yip, R.A. Zakharyan, R.M. Maiorino, R.C. Dart, M.G. Tircus, D. Gonzalez-Ramirez, D.L. Morgan, D. Avram, and M.M. Aposhian. 2000. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. Chemical Research in Toxicology 13: 693-697.

Aposhian, H.V., B. Zheng, M.M. Aposhian, X.C. Le, M.E. Cebrian, W. Cullen, R.A. Zakharyan, M. Ma, R.C. Dart, Z. Cheng, P. Andrewes, L. Yip, G.F. O'Malley, R.M. Maiorino, W. Van Voorhies, S.M. Healy, and A. Titcomb. 2000. DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine. Toxicology and Applied Pharmacology 165: 74-83.

Radabaugh, T.R., and H.V. Aposhian. 2000. Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. Chemical Research in Toxicology 13: 26-30.

Contact Information

Mailing: H. Vasken Aposhian, Professor Department of Molecular & Cellular Biology University of Arizona Biological Sciences West 262 P.O. Box 210106 Tucson, AZ 85721-0106

Telephone: 520-621-7565 (Office) 520-621-7566 (Lab) Fax: 520-621-3709 (Department) Email: aposhian@email.arizona.edu

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