The University of Arizona

Todd Camenisch

Assistant Professor of Pharmacology & Toxicology and Molecular & Cellular Biology
Ph.D., University of North Carolina at Chapel Hill, 1998

The focus of the laboratory is investigating the integration between extracellular matrix and growth factor receptor signaling during heart morphogenesis. The emphasis is on heart septae and valve formation.

Research Interests

We have established that hyaluronan, a matrix sugar, is able to modulate receptor tyrosine kinase activity during early heart valve morphogenesis. We believe the EGFR family of receptors and cognate ligands play integral functions during heart development. This growth factor signaling activity is most likely context specific in regards to matrix components, proteases and growth factor presence. Thus experimental approaches are designed to decipher this complex developmental process.

Select Publications

Any link on the below references will take you off of the BMCB site and to an abstract of that particular paper.

Rodgers, L., S. Lalani, K. Hardy, X. Xiang, D. Broka, P.B. Antin, and T.D. Camenisch. 2006. Depolymerized hyaluronan induces VEGF, a negative regulator of developmental EMT. Circulation Research (in press).

Stevens, M., P. Parker, R.R. Vaillancourt, T.D. and Camenisch. 2006. MEKK4 regulates developmental EMT in the embryonic heart. Developmental Dynamics (in press).

Klewer, S.E., T. Yatskievych, K. Pogreba, M.V. Stevens, P.B. Antin, and T.D. Camenisch. 2006. Has2 expression in heart forming regions is independent of BMP signaling. Gene Expression Patterns 6: 462-470.

Lopez, J.I., T.D. Camenisch, M.V. Stevens, B.J. Sands, J. McDonald, and J.A. Schroeder. 2005. CD44 attenuates metastatic invasion during breast cancer progression. Cancer Research 2005 65: 6755-6763.

Schroeder, J.A., L.F. Jackson, D.C. Lee, and T.D. Camenisch. 2003. Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. Journal of Molecular Medicine 81: 392-403.

McDonald, J.A., and T.D. Camenisch. 2003. Hyaluronan: Genetic insights into the complex biology of a simple polysaccharide. Glycoconjugate Journal 19: 331-339.

Enciso, J.M., D. Gratzinger, T.D. Camenisch, S. Davis, E. Pinter, and J.A. Madri. 2003. Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2. Journal of Cell Biology 160: 605-615.

Schroeder, J.A., M.C. Adriance, M.C. Thompson, T.D. Camenisch, and S.J. Gendler. 2003. MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion. Oncogene 22: 1324-1332.

Dor, Y., S.E. Klewer, J,.A. McDonald, E. Keshet, and T.D. Camenisch. 2003. VEGF modulates early heart valve formation. The Anatomical Record 271: 202-208.

Camenisch, T.D., J.A. Schroeder, J. Bradley, S.E. Klewer, and J.A. McDonald. 2002. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nature Medicine 8: 850-855.

Camenisch, T.D., D.G.M. Molin, A. Person, R. Runyan, A.C. Gittenberger-de Groot, J.A. McDonald, and S.E. Klewer. 2002. Temporal and distinct TGFb ligand requirements during mouse and avian endocardial cushion morphogenesis. Developmental Biology 248: 170-181.

Cohen, P.L., R. Caricchio, V. Abraham, T.D. Camenisch, J.C. Jennette, R.A.S. Roubey, H.S. Earp, G. Matsushima, and E.A. Reap. 2002. Delayed apoptotic cell clearance and Lupus-like autoimmunity in mice lacking the c-mer transmembrane tyrosine kinase. Journal of Experimenal Medicine 196: 135-140.

Dor., Y., T.D. Camenisch, A. Itin, G.I. Fishman, J.A. McDonald, P. Carmeliet, and E. Keshet. 2001. A novel role for VEGF in endocardial cushion formation and its potential contribution to heart septation defects. Development 128: 1531-1538.

Camenisch, T.D., J. Biesterfeldt, T. Brehm-Gibson, J. Bradley, and J.A. McDonald. 2001. Regulation of cardiac cushion development by hyaluronan. Expimental and Clinical Cardiology 6 : 4-10.

Camenisch, T.D., and J. A. McDonald. 2000. Perspective: Hyaluronan-Is bigger better? American Journal of Respiratory Cell and Molecular Biology 23: 431-433.

Camenisch, T.D., A.P. Spicer, T. Brehm-Gibson, J. Biesterfeldt, M.L. Augustine, A. Calabro, Jr., S. Kubalak, S.E. Klewer, and J.A. McDonald. 2000. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. Journal of Clinical Investigation 106: 349-360 (cover).

Lu, Q., M. Gore, Q. Zhang, T.D. Camenisch, S. Boast, F. Casagrande, C. Laio, M. Skinner, R. Klein, G.K. Matsushima, H.S. Earp, S.P. Goff, and G. Lemke. 1999. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-728.

Camenisch, T.D., B.H. Koller, H.S. Earp, and G.K. Matsushima. 1999. A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha and lipopolysaccharide-induced endotoxic shock. Journal of Immunology 162: 3498-3503.

Nguyen, M., T. Camenisch, J.N. Snouwaert, E. Hicks, T.M. Coffman, P.A. Anderson., N.N. Malouf, and B.H. Koller. 1997. The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature 390: 78-81.

Camenisch, T.D., L. Jaso-Friedman, D. Evans, and D.T. Harris. 1993. Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine. Developmental and Comparative Immunology 17: 277-282.

Harris, D.T., T.D. Camenisch, L. Jaso-Friedman, and D. Evans. 1993. Expression of an evolutionary conserved function-associated molecule on sheep, horse, and cattle natural killer cells. Veterinary Immunology and Immunopathology 38: 273-282.

Harris, D.T., R. Kapur, C. Frye, A. Acevedo, T.D. Camenisch, L. Jaso-Fredmann, and D.L. Evans. 1992. A species-conserved NK cell antigen receptor is a novel vimentin-like molecule. Developmental and Comparative Immunology 16: 395-403.

Book Chapters:

Runyan, R. R. Heimark, T.D. Camenisch, and S.E. Klewer. 2004. Epithelial-Mesechymal transformation in the embryonic heart. In: Rise and Fall of Epithelial Phenotype (P. Savagner, Ed.). KluwerAcademic/Plenum Publishers.

Contact Information

    Mailing:
    Todd Camenisch, Assistant Professor
    Department of Pharmacology & Toxicology
    University of Arizona
    Pharmacy 234
    P.O. Box 210207
    Tucson, AZ 85721-0207

    Telephone:
    520-626-0240 (Office)
    520-626-7958 (Lab)

    Fax:
    520-
    626-2466

    Email:
    camenisch@pharmacy.arizona.edu

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