Andrew Capaldi

Assistant Professor of Molecular and Cellular Biology
Ph.D., University of Leeds

The signaling pathways and transcription factors in a cell are organized into circuits that allow cells to process information and make decisions. We are interested in understanding both how these circuits are built from their components and how they function and malfunction. To address these questions we are working to reverse engineer the circuitry that controls cell growth in budding yeast using a combination of genomic, proteomic and computational methods.

Research Interests

The signaling pathways and transcription factors in a cell are organized into circuits that allow cells to process information and make decisions. We are interested in understanding both how these circuits are built from their components and how they function and malfunction. To address these questions we are working to reverse engineer the circuitry that controls cell growth in budding yeast using a combination of genomic, proteomic and computational methods.

Select Publications

Any link on the below references will take you off of the BMCB site and to an abstract of that particular paper.

Capaldi AP, Kaplan T, Liu Y, Habib N, Regev A, Friedman N, O'Shea EK. Nov 2008. Structure and function of a transcriptional network activated by the MAPK Hog1. Nat Genet, 40:1300-6

Spence GR, Capaldi AP, Radford SE. Jul 2004. Trapping the on-pathway folding intermediate of Im7 at equilibrium. J Mol Biol, 341:215-26

Gorski SA, Le Duff CS, Capaldi AP, Kalverda AP, Beddard GS, Moore GR, Radford SE. Mar 2004. Equilibrium hydrogen exchange reveals extensive hydrogen bonded secondary structure in the on-pathway intermediate of Im7. J Mol Biol, 337:183-93

Friel CT, Capaldi AP, Radford SE. Feb 2003. Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins. J Mol Biol, 326:293-305

 

Contact Information

Mailing: Andrew Capaldi , Assistant Professor Department of Molecular & Cellular Biology University of Arizona Life Sciences South 525 P. O. Box 210106 Tucson, AZ 85721-0106

Telephone: 520-626-9376(Office) Email: capaldi@email.arizona.edu

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