BMCB - Faculty Research, David W. Mount

David W. Mount

Professor of Molecular & Cellular Biology and Biochemistry & Molecular Biohysics
Ph.D., University of Toronto

Bioinformatics: sequence and genome analysis, cancer informatics.

Research Interests

Dr. Mount's primary research interest is in applying bioinformatics and genome analysis to cancer research. He leads a computational group at the Arizona Cancer Center that is actively involved in using gene microarray data and other types of data as tools in cancer diagnosis and treatment by trying to predict biochemical and genetic changes (such as single-stranded sequence polymorphisms or SNPs) that increase cancer risk or that cause cancer progression. The computational group also develops databases of clinical and experimental data and transforms these into data warehouses that may be mined to discover new relationships. These studies involve a number of collaborative projects with clinicinas and cancer biologists.
Dr. Mount is also interested in facilitating the collection and storage of sequence and genome data in order to enhance the study of specific cellular processes. In the chromatin project, plant genes that influence chromatin regulation have been identified and compared extensively to genes from other organisms in a collaborative project with colleagues in the Department of Plant Sciences and at other institutions. The chromdb web site at http://www.chromdb.org describes this research. A similar database that provides sequence information, DNA polymorphisms and disease-associations of DNA repair genes in humans, plants and other organisms is also being planned.

Select Publications

Any link on the below references will take you off of the BMCB site and to an abstract of that particular paper.

Calaluce, R., S.K. Beck, E.L. Bair, R. Pandey, K.A. Greer, A.M. Hoying, J.B. Hoying, D.W. Mount, and R.B. Nagle. 2006. Human laminin-5 and laminin-10 mediated gene expression of prostate carcinoma cells. Prostate (in press).

Mount, D.W., and R. Pandey. 2005. Using bioinformatics and genome analysis for new therapeutic interventions. Molecular Cancer Therapeutics 4: 1636-1643.

Pandey, R., R.K. Guru, and D.W. Mount. 2004. Pathway Miner: extracting gene association networks from molecular pathways for predicting the biological significance of gene expression microarray data. Bioinformatics 20: 2156-2158.

Klein, R.R. 3rd, D.W. Mount, and R.B. Nagle. 2004. Modern data security. Archives of Pathology and Laboratory Medicine 128: 338-340.

Chauhan, S., R. Pandey, J.F. Way, T.C. Sroka, M.C. Demetriou, S. Kunz, A.E. Cress, D.W. Mount, and R.L. Miesfeld. 2003. Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation. Biochemical and Biophysical Research Communications 310: 421-432.

Liu, Z., S.W. Hong, M. Escobar, E. Vierling, D.L. Mitchell, D.W. Mount, and J.D. Hall. 2003. Arabidopsis UVH6, a homolog of human XPD and yeast RAD3 DNA repair genes, functions in DNA repair and is essential for plant growth. Plant Physiology 132: 1405-1414.

Pandey, R., A. Muller, C.A. Napoli, D.A. Selinger, C.S. Pikaard, E.J. Richards, J. Bender, D.W. Mount, and R.A. Jorgensen. 2002. Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Nucleic Acids Research 30: 5036-5055.

Liu, Z., J.D. Hall, and D.W. Mount. 2001. Arabidopsis UVH3 gene is a homolog of the Saccharomyces cerevisiae RAD2 and human XPG DNA repair genes. Plant Journal 26: 329-338.

Mount, D.W. 2001. Bioinformatics: Sequence and Genome Analysis, 564 pp. Cold Spring Harbor Press: Cold Spring Harbor, NY. Web site http://www.bioinformaticsonline.org.

Cuddihy, J., and D.W. Mount. 2000. Resources for Sequence and Genome Analysis. Appendix to Molecular Cloning Manual, Sambrook, J., and D. Russell, Eds. Cold Spring Harbor Press.

Selinger, D., R. Pandey, D.W. Mount, V.L. Chandler, R.A. Jorgensen, and C. Pikaard, contributing authors to The Arabidopsis Genome Initiative. 2000. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408: 796-815.

Liu, Z., G.S. Hossain, M.A. Islas, and D.W. Mount. 2000. Repair of UV damage in plants by nucleotide excision repair: Arabidopsis UVH1 DNA repair gene is a homolog of Saccharomyces cerevisiae Rad1 and Human XPF genes. Plant Journal 21: 519-528.

Contact Information

Mailing:
David W. Mount, Professor
Department of Molecular & Cellular Biology
University of Arizona
Arizona Cancer Center 2956
P.O. Box 210106
Tucson, AZ 85721-0106

Telephone:
520-626-0390 (Office)

Fax:
520-621-3709 (Department)

Email:
mount@email.arizona.edu