Jacob Schwartz - Assistant Professor
Our research group is currently studying the role of RNA-binding proteins in neurodegenerative disease. Forty percent of the genes shown to cause amyotrophic lateral sclerosis (ALS) are RNA-binding proteins and two appear to be noncoding RNAs. They are studying four RNA-binding proteins in the lab with the hypothesis that it is the intersection of these genes’ functions that will illuminate the true pathological mechanisms of ALS. They currently are focused on the role these genes play in transcription regulation and DNA damage repair. They also carefully characterize the wild type function of these proteins believing that the wild type function will help us better hypothesize the mutant function.