Ted Weinert - Professor
Our lab has developed systems in budding yeast that allow us to readily identify chromosome changes and study how they were formed. Recently we have made two major findings that we continue to pursue. First, we found that dicentrics, that is, chromosomes with 2 centromeres, play a major role in large-scale changes. Dicentrics have long been known to be associated with chromosome changes, yet how they are normally prevented, and how they form when prevention fails, is unknown and a very active area of research. Second, we are assimilating what is known about replication fork proteins with our studies of the roles of these proteins in preventing chromosome changes.