Seminar
Promotion Talk
When
11 a.m. to 12:15 p.m. Aug. 23, 2022
Location
ENR2 Room S107
Zoom Passcode: MCBSeminar
Faculty Host: Dr. Ted Weinert
When
11 a.m. to 12:15 p.m. May 3, 2022
Professor of Laboratory Medicine and Pathology, University of Washington
"The Dog Aging Project (DAP) is a long-term study of biological aging in companion (pet) dogs. The largest component of the DAP is a longitudinal study of aging, which currently includes more than 33,000 dogs and their citizen-scientist owners. The goals of the longitudinal study are to understand the most important genetic and environmental factors that influence health during aging in dogs. The second major component of the DAP is a clinical trial aimed at testing whether the drug rapamycin (sirolimus) can increase lifespan and healthspan in companion dogs."
Faculty Host: Dr. George Sutphin
When
11 a.m. to 12:15 p.m. April 5, 2022
Location
ENR2 Room S107
Zoom Passcode: MCBSeminar
Faculty Host: Dr. Ted Weinert (MCB)
When
11 a.m. to 12:15 p.m. April 12, 2022
Assistant Professor, Department of Pathology, Stanford University School of Medicine
"Understanding the role of distinct cellular phenotypes in tissue function, development, and pathogenesis requires tools that can rapidly and consistently quantify the expression of multiple proteins while preserving spatial information. To meet this need, we have developed Multiplexed Ion Beam Imaging by Time-Of-Flight (MIBI-TOF). MIBI-TOF uses secondary ion mass spectrometry to visualize up to 50 metal labeled antibodies at subcellular resolution simultaneously with histochemical stains and native biological elements. We have used this capability to study how single cell function and tissue structure interact at the tumor immune microenvironment, the human maternal-fetal interface, and in infectious disease. These studies have led us to develop scalable, automated, and extensible tools for image thresholding, single cell segmentation, cell clustering, and cell neighborhood analyses that can be deployed on any tissue. We are now extending this platform to incorporate coregistered multimodal studies using MALDI that will link tissue structure to glycan composition and extracellular matrix remodeling."
Zoom Passcode: MCBSeminar
When
11 a.m. to 12:15 p.m. April 19, 2022
Associate Professor, Molecular Biology and Genetics Department, Johns Hopkins University School of Medicine
"A fundamental property of living cells is their ability to sense and respond to a changing environment. This versatility is achieved through highly interconnected signaling networks that have been carefully characterized through genetic and biochemical approaches. However, the temporal organization of signaling activities during cell fate decisions remains poorly understood. In order to address these questions, live single cell measurements of signaling and cell fate decisions are critical. In our laboratory we use live cell imaging of genetically encoded biosensors to characterize the temporal organization of signaling activities during mammalian development and tumorigenesis. Specifically, I will discuss our most recent work regarding the role of MAPK signaling network dynamics in preimplantation development and the early stages of cancer."
Faculty Host: Dr. Andrew Paek (MCB)
When
11 a.m. to 12:15 p.m. April 26, 2022
Location
ENR2 Room S107
Associate Professor, Cellular and Molecular Medicine
Hosted by Dr. Guang Yao
When
11 a.m. to 12:15 p.m. Feb. 22, 2022
Location
ENR2 Room S107
Hosted by Dr. Daniela Zarnescu
When
11 a.m. to 12:15 p.m. March 15, 2022
Zoom Passcode: MCBSeminar
Hosted by Dr. Ted Weinert
When
11 a.m. to 12:15 p.m. March 29, 2022
Professor, MCB Division of Immunology and Molecular Medicine, UC Berkeley
How does aging occur? Does each cell determine its own age, regardless of other cells in the body? Or does there exist a hierarchy in which cells coordinate aging across the entire organism so that each tissue and organ age at the same rate? If the latter, which cells and which process would be coordinated, and how? The mechanisms surrounding how individual cells age, whether yeast or mammalian cells grown in culture, have been exhaustively studied and rely on large part to the replicative potential of the cell. However, how cells within an animal age has largely not been explained. Work of the Dillin group has broken down the barriers of metazoan aging to reveal that this process is coordinated across the multiple cell types and not merely left to stochastic chance by each individual cell. Our findings not only reveal which cells perform the coordination, but also the molecules required for communicating aging across cells types and their downstream consequences.
Hosted by Dr. Ted Weinert
When
11 a.m. to 12:15 p.m. March 1, 2022
