• Johnny Fares
    Lysosome Biogenesis in C. elegans Coelomocytes: Shows lysosome biogenesis in a coelomocyte in C. elegans. Endosomes are labeled with RME 8::mRFP (red) and lysosomes with GFP::CUP-5 (green). CUP-5 is the C. elegans orthologue of human TRPML1, mutations in which results in the lysosomal storage disorder Mucolipidosis Type IV. Note the biogenesis of a lysosome from an endosomal compartment in lower left corner.
  • Johnny Fares
    Mucolipidosis Type IV Lysosomal Defects: Shows an expanded endosome/lysosome hybrid compartment in a cup-5 mutant coelomocyte in C. elegans. CUP-5 is the C. elegans orthologue of human TRPML1, mutations in which results in the lysosomal storage disorder Mucolipidosis Type IV. The membrane of the expanded compartment is marked by LMP-1::GFP (green) and contains endocytosed BSA-Rhodamine (red).
  • Lisa Nagy
    This image shows an 8-cell stage of the mud snail Ilyanassa obsoleta embryo that was treated with a chemical antagonist of the NMDA receptor. This treatment disrupts the correct spindle orientation and pPKC localization, suggesting that NMDA receptor signaling is required for cell polarization during the early asymmetric cleavages of the mud snail. Nuclei (blue) are stained with DAPI, microtubules (green) and phosphorylated protein kinase C (pPKC) (red) are stained with their specific antibodies.
  • Michael Wierzba & Frans Tax
    Nomarski image of Arabidopsis thaliana mature embryo containing ProgericPro::GUS transgene, stained with X-Gluc, fixed and cleared.
  • Mamata Pochampalli & Joyce Schroeder
    Whole mounts of WAP-TGF &alpha transgenic mouse mammary glands filled with pre-cancerous hyperplasias overlaying the ductal epithelium of the gland. Inset in upper right corner shows normal non-cancerous ductal epithelium
  • Benjamin Bitler & Joyce Schroeder
    The Epidermal Growth Factor Receptor (green) residing on the membrane of breast cancer cells (cell nuclei in blue).
  • Ina Menzl & Joyce Schroeder
    Immortalized mammary epithelial cells (MCF10A) growing as acini in a basement membrane extracellular matrix. Images represent cellular nuclei from the top (left) through to the middle of the acini.
  • Anthony Bryan & Frans Tax
    Confocal images of an Arabidopsis heart stage embryo, surface view (left) and a medial cross-section (right). These samples are from a wild-type plant with a transgene of the ATML1 promoter driving expression of a nuclear localized YFP. Magnification approximately 40X.
  • Adam Obaidi, Anthony Bryan & Frans Tax
    One vascular bundle from a hand section of a wild-type Columbia Arabidopsis stem, stained with Toluidine Blue and magnified 20X. From top to bottom, the photograph includes pith (pink), xylem (blue), procambium (white.gray), phloem (pink), cortex (brown/green) and epidermis (purple).
  • Joseph Boyd & Carol Dieckmann
    Immunofluorescence micrograph of a wild-type Chlamydomonas reinhardtii cell with flagella and microtubule rootlets (green) stained with anti-acetylated alpha tubulin and eyespot (red) stained with an antibody raised against an eyespot localized protein, EYE3. Unpublished image taken by Joseph Boyd October 30, 2008.
  • Matthew Callan & Daniela Zarnescu
    Drosophila larval brain, immunostained for the stem cell and GMC marker, Worniu (red). Cells in the optic lobe that, through genetic manipulations have become deficient for Fragile X Protein, are labeled in green. DNA shown in blue.

The BMCB graduate program is an interdepartmental and interdisciplinary graduate program that seeks to equip students with the long-term knowledge and skills to succeed in careers in the life sciences. By training students to identify, ask and answer significant open questions in the biological sciences at the molecular level, we ultimately provide them with solid foundational knowledge in multiple areas of biology and help them to develop transferrable skills to adapt to the rapid pace of conceptual and technological advances in biology throughout their careers.

Our graduate program is funded by a training grant from the National Institute of General Medical Sciences (NIGMS)