Johnny Fares : Lysosome Biogenesis in C. elegans Coelomocytes: Shows lysosome biogenesis in a coelomocyte in C. elegans. Endosomes are labeled with RME 8::mRFP (red) and lysosomes with GFP::CUP-5 (green). CUP-5 is the C. elegans orthologue of human TRPML1, mutations in which results in the lysosomal storage disorder Mucolipidosis Type IV. Note the biogenesis of a lysosome from an endosomal compartment in lower left corner. Johnny Fares: Lysosome Biogenesis in C. elegans Coelomocytes: Shows lysosome biogenesis in a coelomocyte in C. elegans. Endosomes are labeled with RME 8::mRFP (red) and lysosomes with GFP::CUP-5 (green). CUP-5 is the C. elegans orthologue of human TRPML1, mutations in which results in the lysosomal storage disorder Mucolipidosis Type IV. Note the biogenesis of a lysosome from an endosomal compartment in lower left corner.

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