Nancy Horton

My laboratory is interested in the structures and mechanisms of proteins that act upon DNA and RNA and their consequences to human health. Currently, we are investigating proteins from the human pathogen, Human Parvovirus B19, and as well as enzymes which modulate their activity using filament formation. The methods we employ include structural techniques such as x-ray crystallography, NMR and cryo-electron microscopy, and functional investigations using biochemical and high-throughput methodologies